LATEX also has some disadvantages, and I guess it’s a bit difficult for me to find any sensible ones, though I am sure other people can tell you hundreds

• LATEX does not work well for people who have sold their souls . . .
• Although some parameters can be adjusted within a predefined document layout, the design of a whole new layout is difficult and takes a lot of time.
• It is very hard to write unstructured and disorganized documents.
• Your hamster might, despite some encouraging first steps, never be able to fully grasp the concept of Logical Markup.

From the “The Not So Short Introduction to LATEX“